A very weird cartoon will probably mean a very weird game.
The game Ugly Americans: Apocalysegeddon is based on a TV show on Comedy Central. If you never watched it I can explain real quick. The main character is a social worker for monsters. He helps them adapt and find a place in the world. They go though some really weird shit. His roomate and friend is a sex obsesed zombie. His co-worker is a drunk wizard. His girlfriend is a sucubus. And his boss is a demon trying to bring the world to it's end. There is also a human cop who is always trying to arrest or kill his monster clients. So yeah it's pretty strange. I'm not sure how they are planning to turn it into a game though. On gamasutra they say it will be a four player side scrolling shooter that you can download for $10. There are supposed to be more details given at E3.